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GMO fish and the strangeness of American salmon

December 2, 2015 — Sometime in the next few years, an entirely new fish will appear on American plates. After several decades of biotech research and a final upstream push past the U.S. Food and Drug Administration last month, the AquaBounty AquAdvantage salmon, a genetically engineered species of fish, will go into commercial production. While modified plants like corn and soy abound in the American diet, this will mark the first time in history that an engineered animal has been approved for human consumption. The new fish’s genetic code is comprised of components from three fish: base DNA from an Atlantic salmon; a growth gene from a Pacific Chinook salmon; and a promoter, a kind of “on” switch for genes, from a knobby-headed eel-shaped creature called an ocean pout.

The salmon’s pathway to the market will involve a similarly complex formulation. The first phase of AquAdvantage production will take place in Canada, on Prince Edward Island. There, the all-female eggs will be rendered sterile through a pressure treatment. They will then be flown to Panama, where they’ll be hatched, raised to harvestable size, slaughtered, and imported into the U.S. as the familiar orange-hued fillets that Americans have come to prefer above all other types of fish. Though AquaBounty hopes that the costs of this circuitous route to market could be offset by the savings incurred from the fish’s rapid growth (the company claims that AquAdvantage reaches maturity in about half the time as unmodified fish), the company is hoping to eventually gain permission to farm the fish here at home. “In the longer run,” AquaBounty’s co-founder, Elliot Entis, wrote me in an e-mail, “the real payoff will be when inland recirculating facilities are built in the U.S.”

Read the full story at The New Yorker

Salmon breakthrough was driven by chance

November 25, 2015 — It was the early 1980s, and a group of Canadian fish farmers was hoping to find a way for salmon to thrive in the region’s frigid waters. So scientists in Newfoundland began experimenting with how to inject them with antifreeze proteins from an eel­-like creature known as ocean pout.

Instead, they found a way to make the fish grow more quickly.

That work, more than 30 years ago, led to the controversial breakthroughs that allowed AquaBounty Technologies, a biotechnology company in Maynard, to produce a rapidly growing salmon, which the Food and Drug Administration last week declared the first genetically altered animal fit for consumption.

“We thought if we can enhance the growth rate, that’s good for the industry, which can get fish to market faster,” said Garth Fletcher, a researcher at Memorial University in Newfoundland, who did the initial experiments that led to the creation of salmon that can grow twice as fast as those in the wild. Fletcher’s technique of inserting growth hormone from Chinook salmon and a “promoter gene” from ocean pout is now considered antiquated technology. But scientists say its commercial application heralds a new era of genetic engineering.  

Federal regulators on Thursday approved a Massachusetts biotechnology company’s bid to modify salmon for human consumption.

“We thought if we can enhance the growth rate, that’s good for the industry, which can get fish to market faster,” said Garth Fletcher, a researcher at Memorial University in Newfoundland, who did the initial experiments that led to the creation of salmon that can grow twice as fast as those in the wild.

Fletcher’s technique of inserting growth hormone from Chinook salmon and a “promoter gene” from ocean pout is now considered antiquated technology. But scientists say its commercial application heralds a new era of genetic engineering.

New techniques have allowed scientists to more precisely alter animal genomes by editing DNA to include or exclude beneficial or harmful traits. Researchers are now experimenting with modifying the genes of chickens so they don’t transfer avian flu, for example. They also want to develop pigs and cattle that are resistant to foot and mouth disease, and goats that produce a higher level of a microbial protein that may help treat diarrhea in people.

Read the full story at the Boston Globe

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